Abstrakt
Spondyloarthritis is a progressive inflammatory disease that typically causes lower back pain and stiffness.Spondyloarthropathies (SpA) are a group of inflammatory arthritis which consist of ankylosing spondylitis (AS), reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA), and arthritis/spondylitis associated with inflammatory bowel diseases.A strong link between human leukocyte antigen B27 and axSpA, however, has been identified, and the success of anti-tumour necrosis factor and anti-interleukin (IL)-17A therapy has highlighted some of the key pro- inflammatory cytokines involved. The anti-IL-17A monoclonal antibody secukinumab is approved for the treatment of Ankylosing spondylitis and nr-axSpA in the European Union and United States
Əsas mətn
Introduction.
Our case report aims to present healing back pain due to IL-17 inhibitor, Secukinumab, in a patient with ax SpA. Case report-32 year old female patient presented with complaint low back pain that persists for more than a year.She took NSAIDs before but it did not help. She had complaint of stiffness in the morning lasts for about 2 hours, and the feeling of pain and stiffness disappears with movement ,redness and pain in the left eyes.There was synovial hypertrophy grade 3 in her left knee.Shesaid his mother had psoriasis. She had no history of serious infectious disease in childhood.He had no fever. There was no smoking or alcohol use. Lab test showed normochromic normocytic anemia (Hb 8.9 gm%), ESR-59 mm /30 min, Crp-29 mg/l, Rf-8.5 IU /ml, ANA –negative, Brucella G/M-negative, HLA - B27-positive ,TSH-78.5 mIU /ml. Quantiferon gold-negativ
Consultation wasrequest from the opthalmology department and the diagnosis was reported as Panuveitis. Steroid eye drops were started and she was referred to the rheumatology department for systemic treatment .We started the patient on Secukinumab 150 mg /week ,Meloxicam 15 mg /day ,Vit D 50000 IU/week ,Calcium ,PPI 40 mg during 2 month ago. The Endocrine department diagnosed Hashimato , Eutirox 150 mkg /day as treatment.
Conclusion
I am sharing with you the the control results after 2 months. During eye control ,his vision was 70 % better .There was no complains of pain or redness. ESR-15 mm /30 min ,Crp-4,8 mg /l ,Rf-8.5 IU /ml ,ALT- 17.7 U /L ,AST-15.7 ,TSH-5.2.Patient felt better.There was no knee pain and swelling , back pain or stiffness in the mornings.The patient was advised to continue her rheumatological treatment and swim 3 days a week .AxSpA, comprising r-axSpA and nr-axSpA, covers a whole spectrum of disease with different courses. Therapy with bDMARDs should be considered for patients who are refractory to first-line NSAIDs. TNF and IL- 17A inhibition were shown to be efficacious in patients whose disease is not adequately controlled by NSAIDs.This clinical results showed us that Secukinumab also helps improve eye symptoms
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Dərc edilib: 29.Jun.2024
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© 2024-2025. Azərbaycan Revmatologiya və İltihab Jurnalı. Azərbaycan Revmatoloqlar Assosiasiyası ilə tərəfdaşlıqda. Jurnal "Uptodate in Medicine" tibb nəşriyyatı tərəfindən dərc olunur. Bütün hüquqlar qorunur.Əlaqəli məqalələr
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