Rheumatology & Inflammation Journal

It is an autoimmune disease of unknown etiology characterized by uncontrolled hyperproduction of autoantibodies against the cell nucleus. Uncontrolled disease activity leads to complications, and complications lead to life threats. Hematologic changes are the most common serious complications of SLE. Thrombocytopenia is detected in 20-25% of SLE patients and is mainly parallel to disease activity. During this disease, thrombocytopenia manifests as primary and secondary. Secondary thrombocytopenia is due to drugs used and intercurrent infection, and primary is due to uncontrolled synthesis of autoantibodies against platelets.

The exact etiology of SpA is unknown. HLA-B27 is the biggest risk factor for the development of SpA. This antigen is very common in AS, a common type of SpA. The role of HLA-B27 in this group of diseases is not clear. The interaction of genetic and environmental factors is important in its pathogenesis. In the ReA subtype, bacterial organisms stimulate disease progression.

The exact etiology of SpA is unknown. HLA-B27 is the biggest risk factor for the development of SpA. This antigen is very common in AS, a common type of SpA. The role of HLAB27 in this group of diseases is unclear. The interaction of genetic and environmental factors is important in its pathogenesis. In the ReA subtype, bacterial organisms stimulate disease progression.